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Roads that run east/west have even numbers. Thus, [[Route 2]] runs from Cambridge, out through Williamstown, and beyond. I-40 runs from Wilmington, NC, to somewhere way out west, past Texas. And Highway/Route 66 is perhaps the most famous example of an American east/west road.
It also helps to know that the numbers [http://www.ihoz.com/viol.html mostly] increase from west to east and south to north (for interstate highways at least).
Knowing this logic can (sort of) help you navigate when you are lost.